| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450961 |
| ISSN: | 1984-8250 |
| Autors: | Azevedo, Fernanda Cristina Rezende1 Vaz, Izabela Cristina Dias2 Barbosa, Francisco Antônio Rodrigues2 Magalhaes, Sérgia Maria Starling1 |
| Institucions: | 1Universidade Federal de Minas Gerais, Colegio de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil |
| Any: | 2019 |
| Volum: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cyanobacteria are phytoplanktonic microorganisms that are susceptible to the deleterious effects of pharmaceutical residues in the aquatic environment, which poses a challenge to the environment exposed to diverse pharmaceutical products and their potential effects. The objective of this study was to evaluate the effects of the antibiotic substances ciprofloxacin and chlorhexidine in pharmaceutical preparations on the growth and production of chlorophyll of two cyanobacterial strains, Microcystis aeruginosa and Microcystis panniformis, isolated from a lake in a Brazilian environmental protection area. The EC50 and EC10 of chlorhexidine for M. aeruginosa were 206.4 µg/L and 108.5 µg/L, respectively, and for M. panniformis were 171.4 µg/L and 116.6 µg/L, respectively. The EC50 and EC10 of ciprofloxacin for M. aeruginosa were 17.24 µg/L and 3.21 µg/L, respectively, and for M. panniformis were 13.56 µg/L and 1.50 µg/L, respectively. The toxicity of the antibiotic ciprofloxacin (drug) and chlorhexidine (standard solution) to the Microcystis species was demonstrated, and these species were both very sensitive to ciprofloxacin. Our results suggest that the strains of M. aeruginosa and M. panniformis may be affected by exposure to residues of ciprofloxacin (>1.5 µg/L), which may represent a risk to the survival of aquatic species |
| Disciplines | Química, Ingeniería |
| Paraules clau: | Ingeniería ambiental, Residuos farmacéuticos, Pruebas toxicológicas, Clorhexidina, Ciprofloxacina, Bioensayos, Inhibición del crecimiento, Cianobacterias |
| Keyword: | Environmental engineering, Pharmaceutical wastes, Toxicological tests, Chlorhexidine, Ciprofloxacin, Bioassays, Growth inhibition, Cyanobacteria |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
