| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451135 |
| ISSN: | 1984-8250 |
| Autors: | Upadhyay, Prabhat1 Shukla, Rashmi2 Tiwari, Kavindra Nath3 Dubey, G P4 Mishra, Sunil Kumar5 |
| Institucions: | 1Banaras Hindu University, Department of Pharmacology, Varanasi, Uttar Pradesh. India 2Banaras Hindu University, Department of Medicinal Chemistry, Varanasi, Uttar Pradesh. India 3MMV Banaras Hindu University Varanasi, Department of Botany, Varanasi, Uttar Pradesh. India 4Banaras Hindu University, Institute of Medical Sciences, Varanasi, Uttar Pradesh. India 5Banaras Hindu University, Department of Pharmaceutical, Engineering and Technology, Varanasi, Uttar Pradesh. India |
| Any: | 2019 |
| Volum: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg |
| Disciplines | Química |
| Paraules clau: | Farmacología, Fitoquímica, Plantas medicinales, Hojas, Análisis toxicológico, Histopatología, Reinwardtia indica, Linaceaae |
| Keyword: | Pharmacology, Phytochemistry, Medicinal plants, Leaves, Toxicological analysis, Histopathology, Reinwardtia indica, Linaceae |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
