| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451081 |
| ISSN: | 1984-8250 |
| Autors: | Riaz, Muhammad Ijaz1 Sarwar, Hafiz Shoaib1 Rehman, Mubashir3 Gohar, Umar Farooq1 Raza, Syed Atif4 Siddique, Muhammad Irfan5 Shahnaz, Gul2 Sohail, Muhammad Farhan1 |
| Institucions: | 1University of Lahore, Riphah Institute of Pharmaceutical Sciences, Lahore, Punjab. Pakistán 2Quaid-i-Azam University, Faculty of Biological Sciences, Islamabad. Pakistán 3University of Central Punjab, Faculty of Pharmacy, Lahore, Punjab. Pakistán 4University of the Punjab, University College of Pharmacy, Lahore, Punjab. Pakistán 5University of Veterinary and Animal Sciences, Institute of Pharmaceutical Sciences, Lahore, Punjab. Pakistán |
| Any: | 2019 |
| Volum: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were applied to achieve maximum optimized drug loading. A HPLC method was validated for drug quantification in erythrocytes. The relatively high loading was achieved using hypotonic treatment was 31.39% as compared to other two methods. These, drug loaded erythrocytes were characterized for membrane integrity via ESR showing higher ESR values for drug loaded cells as compared to normal cells. Moreover, microscopic evaluation was done to observe morphological changes in erythrocytes after successful loading which showed swollen cells with slight rough surface as compared to smooth surface of normal cells. Drug release was studied for 8 h which showed more than 80% release within 3-7 h from erythrocytes treated with different hypotonic methods. Overall, the study revealed a potential application of erythrocytes in delivery of hydrophobic drugs using hypotonic treatment as compared to other methods |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Sistemas de liberación de fármacos, Fármacos hidrofóbicos, Artemeter, Acarreadores, Eritrocitos |
| Keyword: | Medicinal chemistry, Drug delivery systems, Hydrophobic drugs, Artemether, Erythrocytes, Carriers |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
