| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451969 |
| ISSN: | 1984-8250 |
| Autors: | Lim, Oon Zhi1 Yeoh, Boon Seng1 Omar, Norsuhana1 Mohamed, Mahaneem1 Zin, Anani Aila Mat2 Ahmad, Rozaziana1 |
| Institucions: | 1Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan. Malasia 2Hospital Sultan Abdul Halim, Department of Medicine, Sungai Petani, Kedah. Malasia |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Background and aim: Stingless bee propolis, a resinous compound processed by mandibular secretion of stingless bees, is used for maintenance of hygiene and stability of beehives. Research on stingless bee propolis shows therapeutic properties attributed to polyphenols exhibiting antioxidative, antihyperglycemic and antiischemic effect. However, the cardioprotective effect of stingless bee propolis on diabetic cardiomyopathy is unknown. Methods: Adult male Sprague Dawley rats were randomised to five groups: normal group, diabetic group, diabetic given metformin (DM+M), diabetic given propolis (DM+P) and diabetic given combination therapy (DM+M+P) and treated for four weeks. Body weight, fasting blood glucose, food and water intake were taken weekly. At the end of experiment, biomarkers of oxidative damage were measured in serum and heart tissue. Antioxidants in heart tissue were quantified. Part of left ventricle of heart was processed for histological staining including Haematoxylin and Eosin (H&E) stain for myocyte size and Masson’s Trichrome (MT) stain for heart fibrosis and perivascular fibrosis. Results: Propolis alleviated features of diabetic cardiomyopathy such as myocyte hypertrophy, heart fibrosis and perivascular fibrosis associated with improvement in antioxidative status. Conclusion: This study reports beneficial effect of propolis and combination with metformin in alleviating histopathological feature of diabetic cardiomyopathy by modulating antioxidants, making propolis an emerging complementary therapy |
| Disciplines | Medicina |
| Paraules clau: | Endocrinología, Cardiología, Farmacología, Propóleo, Metformina, Actividad antioxidante, Cardiomiopatía diabética |
| Keyword: | Endocrinology, Cardiology, Pharmacology, Propolis, Metformin, Antioxidant activity, Diabetic cardiomyopathy |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
