Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451735 |
ISSN: | 1984-8250 |
Autors: | Vyas, Navya1 Punchathidil, Rakhi1 Swain, Ansuman1 Shakeer, Irfan1 Reddy, Badikol Shrikar2 Manu, Mohan Kamalanivas1 Miraj, Sonal Sekhar1 |
Institucions: | 1Manipal Academy of Higher Education, Prasanna School of Public Health, Manipal, Karnataka State. India 2Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka State. India |
Any: | 2022 |
Volum: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | The bidirectional relationship between tuberculosis (TB) and diabetes mellitus (DM) is a major concern for medical professionals and epidemiologists as DM affects the severity, progress and outcome of TB and vice versa. Patients affected with TB have a higher rate of morbidity, treatment failure and mortality. Likewise, DM triples the risk of contracting TB and therefore poses a threat to the progress made in the reduction of TB incidence. Hence, it is pivotal to address both the diseases keeping in mind the each other. It is known that adjunct therapy with immunomodulatory drugs can enhance TB immunity among diabetic patients. Metformin, a commonly used anti-diabetic drug with adenosine monophosphate-activated protein kinase (AMPK) activation property, has shown the capacity to reduce the growth of Mycobacterium tuberculosis within the cell. This drug inhibits the mitochondrial complex and possesses anti-inflammatory action. Therefore, Metformin can be considered as an ideal molecule for host-directed or host-targeted therapy for TB |
Disciplines | Medicina |
Paraules clau: | Farmacología, Endocrinología, Microbiología, Diabetes, Tuberculosis, Comorbilidad, Metformina, AMPK |
Keyword: | Pharmacology, Endocrinology, Microbiology, Diabetes, Tuberculosis, Comorbidity, AMPK, Metformin |
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