Quercetin modulates age-induced changes in the transcript levels of some apoptosis related genes in the skeletal muscles of male rats
Título del documento: Quercetin modulates age-induced changes in the transcript levels of some apoptosis related genes in the skeletal muscles of male rats
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451236
ISSN: 1984-8250
Autors: 1
1
1
1
Institucions: 1Tanta University, Faculty of Science, Tanta, Gharbia. Egipto
Any:
Volum: 56
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Adverse changes occur gradually in the skeletal muscles with age via continuous exposure to oxidative stress. Quercetin, a member of the flavonoids family, possesses anti-oxidative and radical-scavenging activities. Therefore, this study investigated the role of quercetin to modulate age-induced changes in the transcript levels of some apoptosis-related genes in rat’s gastrocnemius muscles, up to 15 months-old. Half of the rats at each age (1, 5, 10 and 15 months old) were given a vehicle and the other half was given 200 mg/kg quercetin for 2 weeks, respectively. With the increase of age, vehicle groups showed hyalinization of the muscle fibers and a decrease of the catalase and an increase of the malondialdehyde levels. Down-regulation of Bcl2 gene and up-regulation of both NF-κB and Bax genes were recorded. Interestingly, quercetin groups showed focal hyalinization of the muscle fibers at both 10th and 15th months old. An increase in the catalase and a decrease in malondialdehyde levels, up-regulation of Bcl2 gene and down-regulation of both NF-κB and Bax genes were recorded. In conclusion, quercetin minimized age-induced alteration in the morphological structure and the expression of the apoptosis-related genes via increasing the antioxidant defense in the gastrocnemius muscle
Disciplines Biología,
Química
Paraules clau: Biología celular,
Bioquímica,
Envejecimiento celular,
Apoptosis,
Modulación,
Caspasas,
Quercetina,
Histopatología
Keyword: Cell biology,
Biochemistry,
Cell aging,
Apoptosis,
Modulation,
Caspases,
Quercetin,
Histopathology
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