Preparation and characterization of naftifine-loaded poly(vinyl alcohol)/sodium alginate electrospun nanofibers
Título del documento: Preparation and characterization of naftifine-loaded poly(vinyl alcohol)/sodium alginate electrospun nanofibers
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451287
ISSN: 1984-8250
Autors: 1
2
1
2
1
Institucions: 1Istanbul University, Faculty of Pharmacy, Estambul. Turquía
2Istanbul Technical University, Polymer Science and Technology, Estambul. Turquía
Any:
Volum: 56
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés In this study, naftifine (a topical antifungal drug) loaded poly(vinyl) alcohol (PVA)/sodium alginate (SA) nanofibrous mats were prepared using the single-needle electrospinning technique. The produced nanofibers were crosslinked with glutaraldehyde (GTA) vapor. The morphology and diameter of the electrospun nanofibers were studied by scanning electron microscopy (SEM). SEM images showed the smoothness of the nanofibers and indicated that the fiber diameter increased with crosslinking and drug loading. Atomic force microscopy (AFM) images confirmed the uniform production of the scaffolds, and elemental mapping via energy dispersive X-ray spectroscopy (EDS) showed the uniform distribution of the drug within the nanofibers. An attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy study demonstrated that naftifine has sufficient secondary interactions with the polymer blend. The crosslinking treatment decreased the burst drug release effectively and the release mechanism followed Korsmeyer-Peppas Super Case-II transport. Overall, these findings suggest the potential use of naftifine-loaded PVA/SA nanofibers as a topical antifungal drug delivery system
Disciplines Química
Paraules clau: Química farmacéutica,
Antifúngicos,
Naftifina,
Liberación tópica,
Nanofibras,
Alcohol polivinílico,
Alginato de sodio,
Electrohilado
Keyword: Medicinal chemistry,
Antifungal agents,
Naftifine,
Nanofibers,
Poly(vinyl alcohol),
Sodium alginate,
Electrospinning,
Topic delivery
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