| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451218 |
| ISSN: | 1984-8250 |
| Autors: | Gong, Chan Chan1 Li, Tong Tong1 Pei, Dong Sheng1 |
| Institucions: | 1Xuzhou Medical University, Department of Pathology, Xuzhou, Jiangsu. China |
| Any: | 2020 |
| Volum: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis |
| Disciplines | Medicina |
| Paraules clau: | Oncología, Biología celular, Cáncer, Fisiopatología, Receptores androgénicos, Blancos terapéuticos, Cinasa activada |
| Keyword: | Oncology, Cell biology, Cancer, Physiopathology, Androgen receptors, Therapeutic targets, Activated kinase |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
