| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452224 |
| ISSN: | 1984-8250 |
| Autors: | Nugraha, Dwianto Harry1 Anggadiredja, Kusnandar2 Rachmawati, Heni1 |
| Institucions: | 1Institut Teknologi Bandung, School of Pharmacy, Kota Bandung, Jawa Barat. Indonesia |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs. In this minireview, the functional properties of poloxamer for physicochemical modification, such as solubility and stability, and biological response modification, such as neuroprotection, cell apoptosis, efflux pump modification, membrane cell modification, and cellular uptake, are discussed to provide a broader understanding to assist the development of poloxamer-based formulations |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Liberación de fármacos, Polímeros biocompatibles, Poloxámero |
| Keyword: | Medicinal chemistry, Drug delivery, Biocompatible polymers, Poloxamer |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
