| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451255 |
| ISSN: | 1984-8250 |
| Autors: | Sangeetha, Ragupathy1 |
| Institucions: | 1Vels Institute of Science, Technology and Advanced Studies, Department of Biochemistry, Chennai, Tamil Nadu. India |
| Any: | 2020 |
| Volum: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | The therapeutic approaches for Type 2 Diabetes Mellitus rely most on the usage of oral hypoglycaemic drugs. These drugs have adverse side effects and hence alternative medicines are continuously explored. The present study intends to investigate the antidiabetic potential of the flavonoids present in Gracilaria corticata. The flavonoids were isolated (FEGC) and their inhibitory activity on the carbohydrate hydrolysing enzymes such as α-amylase and α-glucosidase was analysed. The flavonoids were found to inhibit α-amylase and α-glucosidase with an IC50 value of 302 µg and 75 µg respectively. The synergistic effect of FEGC and luteolin was also investigated and the results show that both FEGC and luteolin inhibited synergistically at half their IC50 values. The observations of this study reveal that the flavonoids of G. corticata have potential antidiabetic activity and can act independently or synergistically in the management of Type 2 Diabetes Mellitus |
| Disciplines | Química, Medicina |
| Paraules clau: | Fitoquímica, Farmacología, Diabetes, Algas, Flavonoides, Luteolina, Hipoglucemiantes, Sinergismo, Gracilaria corticata, Gracilariaceae |
| Keyword: | Phytochemistry, Pharmacology, Diabetes, Algae, Flavonoids, Luteolin, Hypoglycemic agents, Synergism, Gracilaria corticata, Gracilariaceae |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
