| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451723 |
| ISSN: | 1984-8250 |
| Autors: | Brandolt, Tchana Martinez1 Klafke, Gabriel Baracy2 Ramos, Daniela Fernandes1 Halicki, Priscila Cristina Bartolomeu1 Vicenti, Juliano Rosa de Menezes3 Pereira, Willian Alikuri3 Poester, Vanice Rodrigues1 Sanchotene, Karine Ortiz2 Xavier, Melissa Orzechowski1 |
| Institucions: | 1Universidade Federal do Rio Grande, Programa de Pos-graduacao em Ciencias da Saude, Rio Grande, Rio Grande do Sul. Brasil 2Universidade Federal do Rio Grande, Faculdade de Medicina, Rio Grande, Rio Grande do Sul. Brasil 3Universidade Federal do Rio Grande, Escola de Quimica e Alimentos, Rio Grande, Rio Grande do Sul. Brasil |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Sporothrix spp. are the major dimorphic fungus associated with a type of subcutaneous mycosis, sporotrichosis. The limitation of antifungal availability and the past reports of in vitro resistance of Sporothrix spp. clinical isolates makes it important to search for new compounds with antifungal activities. In this study, we therefore evaluate the in vitro activities of complexes coordinated with Co(II) and cobalt chloride hexahydrate against clinical isolates of Sporothrix spp. Broth microdilution test was performed as per M38-A2 from CLSI (2008) in duplicate for 31 clinical isolates of Sporothrix spp. (27 S. brasiliensis e 04 S. schenckii stricto sensu). The antifungal activities of the complexes coordinated with Co(II) and cobalt chloride hexahydrate were detected at a concentration range of 32-128 µg/mL for all isolates. None of the compounds demonstrated any cytotoxicity (to macrophage cells) at the concentration of 200 µg/mL. The activity against Sporothrix spp. recorded in this study instigate the continuity of experimental studies with Co(II) to search for the mechanisms of antifungal action as well as to evaluate its interaction with the commercial antifungal drugs |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Antifúngicos, Hexahidrato de cloruro de cobalto, Itraconazol, Susceptibilidad, Sporothrix brasiliensis |
| Keyword: | Medicinal chemistry, Antifungal agents, Cobalt chloride hexahydrate, Itraconazole, Susceptibility, Sporothrix brasiliensis |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
