| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450972 |
| ISSN: | 1984-8250 |
| Autors: | Panchangam, Rajeeva Lochana1 Upputuri, Ravi Theaj Prakash2 |
| Institucions: | 1VIT University, School of Bio Sciences and Technology, Vellore, Tamil Nadu. India 2CMR Institute of Management Studies, Department of Bioscience, Bangalore, Karnataka. India |
| Any: | 2019 |
| Volum: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | One of the important fields in nanotechnology is the development of an environment friendly method for the synthesis of nanoparticles. Many approaches show that microorganisms are the most reliable tools for biosynthesis of nanoparticles compared to physical and chemical methods. In our study, fungi have been exploited for extracellular production of metal nanoparticles. It was observed that in Scedosporium, silver ions are reduced to silver nanoparticles, which was confirmed by UV-visible spectrophotometry and AFM. Optimization studies showed that as the concentration of AgNO3 used for synthesis increased, particles’ size also increased. Size of the particles at different concentrations of AgNO3 was observed to be 79-107 nm with particles being ellipsoidal to spherical in shape. Silver nanoparticles synthesized from 2.0 mM silver nitrate, showed maximum antimicrobial activity compared to all antibiotics tested including synergistic effects. In vitro cytotoxicity of silver nanoparticles against MCF 7 and PC 3 showed that as the concentration of silver nanoparticles increased, a decrease in the percentage cell viability was observed with IC50 values being 60.09 and 57.43 µg/ml respectively. Therefore, through this study, it could be said that extracellular synthesis of silver nanoparticles from Scedosporium was simple, ecofriendly, proving excellent antimicrobial and anticancer agents |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Biotecnología, Nanopartículas de plata, Síntesis química, Citotoxicidad, Microscopía de fuerza atómica, Scedosporium |
| Keyword: | Medicinal chemistry, Biotechnology, Silver nanoparticles, Chemical synthesis, Cytotoxicity, Atomic force microscopy, Scedosporium |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
