| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452179 |
| ISSN: | 1984-8250 |
| Autors: | Khader, Syed Zameer Ahmed1 Ahmed, Sidhra Syed Zameer1 Mahboob, Mohamed Rafi2 Prabaharan, Selva Barathi1 Lakshmanan, Shanmugasundaram Olapalayam3 Kumar, Kishore Ramesh1 David, Daniel1 |
| Institucions: | 1K.S.Rangasamy College of Technology, Department of Biotechnology, Tiruchengode, Tamil Nadu. India 2C. Abdul Hakeem College, Department of Physics, Vellore, Tamil Nadu. India 3K.S.Rangasamy College of Technology, Department of Textile Technology, Tiruchengode, Tamil Nadu. India |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Traditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity against lung cancer cell line (A549). FTIR result of synthesised AgNPs reveals the presence of functional group OH as capping agent. XRD pattern confirms the crystalline nature of the AgNPs with peaks at 38º, 44º, 64º and 81º, indexed by (111), (200), (220) and (222) in the 2θ range of 10-90, indicating the face centered cubic (fcc) structure of metallic Ag. HR- TEM results confirm the morphology of AgNPs as almost spherical with high surface areas and average size of 42 ± 9nm. EDX spectra confirmed that Ag is only the major element present and the Dynamic light scattering (DLS) assisted that the Z-average size was 203nm and 1.0 of PdI value. Zeta potential showed − 26.5mv with a single peak. The results of the biological activities of AgNPs exhibited dose dependent activity with 68.44% for arthritic, antiinflammatory with 63.32% inhibition and anti-proliferative activity illustrated IC50 value of 59.66 μg/mL expressing the potential of AgNPs to combat cancer |
| Disciplines | Química |
| Paraules clau: | Farmacología, Nanopartículas de plata, Dátil, Química verde, Actividad antiinflamatoria, Artritis, Phoenix dactylifera, Arecaceae |
| Keyword: | Pharmacology, Silver nanoparticles, Date, Green chemistry, Antiinflammatory activity, Arthritis, Phoenix dactylifera, Arecaceae |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
