| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452215 |
| ISSN: | 1984-8250 |
| Autors: | Guo, Xiang1 Guo, Wei2 Li, Tiandi3 Liu, Fen4 Zhou, Jinpeng1 Guo, Meiqiong1 |
| Institucions: | 1Shenzhen Prevention and Treatment Center for Occupational Disease, Emergency Management Office, Shenzhen, Guangdong. China 2The First Affiliated Hospital of Nan Chang University, Medical Affairs Department, Nanchang, Jiangxi. China 3Shenzhen Prevention and Treatment Center for Occupational Disease, Chemical Analysis and Physical Testing Institute, Shenzhen, Guangdong. China 4Shenzhen Prevention and Treatment Center for Occupational Disease, Quality Control Department, Shenzhen, Guangdong. China |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Evaluation of montmorillonite for paraquat by in vitro and in vivo test. In vitro test were evaluated by a batch test, taking the paraquat concentration, adsorbents, reaction environment and time as indices, the absorption rate was screened by orthogonal design. In vivo test was executed with rabbits. Group 1: 4 rabbits dosed with montmorillonite. Group 2: 8 rabbits dosed with 200 mg/kg paraquat. Group 3: 6 rabbits dosed with 200 mg/kg paraquat then gavage with montmorillonite 5 min later. Group 4: 6 rabbits dosed with 200 mg/kg paraquat then gavage with montmorillonite 30 min later. Blood paraquat concentration, serum cytokines, blood gas analysis and histopathology of lung were implemented. In vitro test found that all the four factors influence the absorption rate of paraquat (P < 0.05). In vitro test found that oral montmorillonite could change toxicokinetics parameters of paraquat (P < 0.05); decrease raised serum TGF-β1 and HMGB1 (P < 0.05) and alleviate the histopathology damage of lung. Montmorillonite might exert its protective effects on paraquat induced damage |
| Disciplines | Medicina |
| Paraules clau: | Toxicología, Farmacología, Intoxicación, Paraquat, Montmorillonita, Toxicocinetica, Histopatología |
| Keyword: | Toxicology, Pharmacology, Intoxication, Paraquat, Montmorillonite, Toxicokinetics, Histopathology |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
