| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451933 |
| ISSN: | 1984-8250 |
| Autors: | Ibrahim, Nik Nor Izah Nik1 Rahman, Razlina Abdul1 Azlan, Maryam2 Rasool, Aida Hanum Ghulam1 |
| Institucions: | 1University Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan. Malasia 2University Sains Malaysia, School of Health Sciences, Kubang Kerian, Kelantan. Malasia |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | To compare global endothelial function assessed by pulse wave analysis (PWA) using the ratio of endothelium dependent vasodilatation (EDV) to endothelium independent vasodilatation (EIV) in patients with hypercholesterolemia and controls. 92 subjects [46 hypercholesterolemics, 46 controls] were studied at standardized conditions. Baseline augmentation index (AIx) was assessed followed by the administration of 0.5 mg sublingual nitroglycerine, an endothelium independent vasodilator. AIx was assessed and the maximum change in AIx after nitroglycerine was recorded as EIV. After a washout period of 30 minutes, 400 µg of inhaled salbutamol, an endothelium dependent vasodilator was administered. AIx was assessed again and the maximum change in AIx after salbutamol was recorded as EDV. Global endothelial function was calculated as EDV:EIV ratio. EDV and EIV in patients with hypercholesterolemia compared to controls were 2.97 ± 3.95 and 6.65 ± 3.80 (p<0.001); and 13.41 ± 4.57 and 15.88 ± 4.78 (p=0.01) respectively. EDV:EIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls; 0.21 ± 0.38 and 0.44 ± 0.24 (p<0.001) respectively. EDV:EIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls. PWA is a potential clinical tool to assess global endothelial function in patients with hypercholesterolemia |
| Disciplines | Medicina |
| Paraules clau: | Sistema cardiovascular, Metabolismo y nutrición, Diagnóstico, Función endotelial, Vasodilatación, Análisis de onda de pulso |
| Keyword: | Cardiovascular system, Metabolism and nutrition, Diagnosis, Endothelial function, Vasodilatation, Pulse wave analysis |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
