| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451315 |
| ISSN: | 1984-8250 |
| Autors: | Brito, Thais Morais de1 Amendoeira, Fabio Coelho1 Oliveira, Temistocles Barroso de2 Frutuoso, Valber da Silva3 Ferraris, Fausto Klabund1 Valverde, Simone Sacramento2 |
| Institucions: | 1Fundacao Instituto Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Saude, Rio de Janeiro. Brasil 2Fundacao Instituto Oswaldo Cruz, Instituto de Tecnologia em Farmacos, Rio de Janeiro. Brasil 3Fundacao Instituto Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil |
| Any: | 2020 |
| Volum: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Solidago chilensis Meyen (= Solidago microglossa) popularly known as “Brazilian arnica” is used to treat of inflammatory disorders. S. chilensis is constant in the Therapeutic Memento of the Rio de Janeiro city and belongs to the medicinal species of Brazilian National List of Medicinal Plants of Interest of the Unified National Health System (SUS). There are no studies in the literature showing the direct activity of this plant species on immune system cells. The present study evaluated the chemical composition as well as the cytotoxic and pharmacological activity of the ether-ethanol extract from S. chilensis inflorescences (SCIE) in murine macrophage cell line J774A.1. The results showed that higher concentrations (50 to 200 µg/mL) of SCIE had significant cytotoxicity on J774A.1 cells, however, lower concentrations (from 10 to 0.1 µg/mL) did not produce significant cytotoxic effects and exhibited an inhibitory effect on nitric oxide production in LPS-stimulated J774A.1 cell line. The chemical analysis by HPLC-UV-PDA indicated that the SCIE contains flavonoid derived from quercetin and kaempferol; and diterpenes, probably labdanes. These findings complement data in the literature regarding the activity of this plant species on an important cell from the immune system involved in the innate and acquired immune response, the macrophages |
| Disciplines | Química, Medicina |
| Paraules clau: | Farmacología, Fitoquímica, Plantas medicinales, Diterpenos, Flavonoides, Actividad antiinflamatoria, Inflorescencias, Solidago chilensis, Asteraceae |
| Keyword: | Phytochemistry, Pharmacology, Anti-inflammatory activity, Medicinal plants, Flavonoids, Diterpenes, Inflorescences, Solidago chilensis, Asteraceae |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
