Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451092 |
ISSN: | 1984-8250 |
Autors: | Güven, Umay Merve1 Berkman, Murat Sami2 Şenel, Behiye3 Yazan, Yasemin2 |
Institucions: | 1Cukurova University, Faculty of Pharmacy, Adana. Turquía 2Anadolu University, Faculty of Pharmacy, Eskisehir. Turquía 3Anadolu University, Faculty of Pharmacy, Eskisehir. Turquía |
Any: | 2019 |
Volum: | 55 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Aplicado, descriptivo |
Resumen en inglés | Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times following application can lead to insufficient treatment of ocular allergies. With this in mind, the aim of this study was to prepare a controlled ocular delivery system to extend the retention time of olopatadine hydrochloride (OLO) and in doing so to reduce the need for frequent application. We developed extended-release ocular in situ gelling systems for which in vivo retention times were determined in sheep following in vitro characterization and cytotoxicity studies. In vivo results were then compared to commercially available Patanol eye drops. the transparent gels formulated using appropriate amounts of polymers and having longer ocular retention times appear to be a viable alternative to commercially available eye drops |
Disciplines | Química, Medicina |
Paraules clau: | Química farmacéutica, Oftalmología, Alergia, Ojos, Clorhidrato de olopatadina, Gelificación |
Keyword: | Medicinal chemistry, Ophthalmology, Allergy, Eyes, Olopatadine hydrochloride, Gelation |
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