| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450958 |
| ISSN: | 1984-8250 |
| Autors: | Bastos, Leandro Francisco Silva1 Vago, Juliana Priscila2 Caux, Thaís Rolla2 Costa, Bruna Lopes2 Godin, Adriana Martins2 Menezes, Raquel Rezende2 Pena, Roberta Ribas1 Silva-Cunha, Armando2 Sousa, Lirlandia Pires2 Machado, Renes Resende2 Moraes, Márcio Flávio Dutra1 Fialho, Sílvia Ligório3 Coelho, Márcio Matos2 |
| Institucions: | 1Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 3Fundacao Ezequiel Dias, Pesquisa e Desenvolvimento Farmaceutico, Belo Horizonte, Minas Gerais. Brasil |
| Any: | 2019 |
| Volum: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the sciatic nerve was performed in Wistar rats. The electronic von Frey test was applied to assess mechanical allodynia. The dexamethasone-loaded implant was placed perineurally at the moment of CCI or 12 days after surgery. Dorsal root ganglia (DRG; L4-L5) were harvested and nuclear extracts were assayed by Western blot for detection of nuclear factor (NF)-κB p65/RelA translocation. Dexamethasone delivered from the implant delayed the development of allodynia for approximately three weeks in CCI rats when the implantation was performed at day 0, but allodynia was not reversed when the implantation was performed at day 12. NF-κB was activated in CCI rat DRG compared with naïve or sham animals (day 15), and dexamethasone implant inhibited p65/RelA translocation in CCI rats compared with control. This study demonstrated that the dexamethasone-loaded implant suppresses allodynia development and peripheral neuroinflammation. This device can reduce the potential side effects associated with oral anti-inflammatory drugs |
| Disciplines | Medicina, Química |
| Paraules clau: | Neurología, Química farmacéutica, Medcina experimental, Constricción nerviosa crónica, Dolor neuropático, Factor nuclear kappa B, Neuralgia, Nervio ciático, Dexametasona, Dispositivos de liberación, Implantes bioabsorbibles |
| Keyword: | Neurology, Medicinal chemistry, Experimental medicine, Chronic constriction injury, Dexamethasone, Delivery device, Neuropathic pain, Nuclear factor kappa B, Neuralgia, Sciatic nerve, Bioabsorbable implants |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
