Assessment of cytotoxicity, genotoxicity, and mutagenicity of the dexchlorpheniramine reference standard and pharmaceutical formula in human peripheral blood mononuclear cells
Título del documento: Assessment of cytotoxicity, genotoxicity, and mutagenicity of the dexchlorpheniramine reference standard and pharmaceutical formula in human peripheral blood mononuclear cells
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451769
ISSN: 1984-8250
Autores: 1
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Instituciones: 1Universidade Federal do Pampa, TOXCEL - Grupo de Pesquisa em Toxicologia Celular, Uruguaiana, Rio Grande do Sul. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Dexchlorpheniramine is a first-generation classical antihistamine, clinically used to treat allergies. The main objective of our study was to evaluate the effects of the dexchlorpheniramine reference standard (DCPA Ref. St) and a pharmaceutical formula on DNA in human peripheral blood mononuclear cells (PBMCs). We exposed PBMCs to five different concentrations (0.5, 2.5, 5, 10, and 50 ng/mL) of DCPA Ref. St DCPA Ref. St and pharmaceutical formula in order to evaluate their cytotoxic, genotoxic, and mutagenic potential. The results showed that both dexchlorpheniramine formulations did not affect PBMC viability and CD3+, CD4+, or CD8+ lymphocyte subpopulations. The DCPA Ref. St and pharmaceutical formula neither induced genotoxic or mutagenic effects nor numerical or structural chromosomal alterations in PBMCs after 24 hours of exposure
Disciplinas: Química,
Medicina
Palabras clave: Química farmacéutica,
Antihistamínicos,
Dexclorfeniramina,
Bioensayos,
Citotoxicidad,
Genotoxicidad,
Mutagenicidad,
Células mononucleares
Keyword: Medicinal chemistry,
Antihistaminics,
Dexchlorpheniramine,
Bioassays,
Cytotoxicity,
Genotoxicity,
Mutagenicity,
Mononuclear cells
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