Mineralocorticoid modulation of central angiotensin-induced neuronal activity, water intake and sodium appetite



Título del documento: Mineralocorticoid modulation of central angiotensin-induced neuronal activity, water intake and sodium appetite
Revista: Brazilian journal of medical and biological research
Base de datos: PERIÓDICA
Número de sistema: 000350347
ISSN: 0100-879X
Autors: 1
1
1
Institucions: 1Universite Henri Poincare-Nancy I, Faculte de Medecine, Nancy, Meurthe-et-Moselle. Francia
Any:
Període: May
Volum: 40
Número: 5
Paginació: 699-705
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Central angiotensin II (AngII) stimulates water and salt solution intake. Pretreatment with low-dose mineralocorticoid (DOCA) enhances this AngII-induced intake of salt solutions (the synergy theory) in Wistar and Sprague Dawley rats but not in Fischer rats. This response is mediated via the AT-1 receptor. Electrophysiological experiments using iontophoretic application of AngII and the AT-1 receptor-specific non-peptide antagonist losartan showed excitation of neurons in the preoptic/medial septum region of urethane-anesthetized male Wistar rats. DOCA pretreatment further enhances this neuronal excitation in response to AngII and reduces the responses to losartan. This generated the hypothesis that DOCA-enhanced AngII-induced neuronal excitation is the neural support for the synergy theory. AT-2 receptors modulate these intake responses depending on sodium in the diet, and diuretic-induced dehydration during pregnancy produces a higher salt intake in the offspring. AngII-induced salt and water intakes were tested in offspring from Sprague Dawley mothers with only 1.8% NaCl to drink in which half were treated with furosemide. The important observations were a) the AT-1 antagonist alone suppressed intakes in offspring from mothers not treated with furosemide, b) both AT-1 and AT-2 antagonists suppressed intakes in offspring from furosemide-treated mothers, and c) combined administration of AT-1 and AT-2 antagonists greatly suppressed water intake in offspring from mothers not treated with furosemide. These results suggest that AT-1 and AT-2 receptors have variable properties (receptor number and/or second messengers). Furthermore, the activity and function of these central AngII receptors depend on the background mineralocorticoid levels. The exact mechanism of this influence, however, remains to be determined
Disciplines Medicina
Paraules clau: Endocrinología,
Neuroendocrinología,
Aldosterona,
Actividad neuronal,
Mineralocorticoides,
Iontoforesis
Keyword: Medicine,
Endocrinology,
Neuroendocrinology,
Aldosterone,
Neuronal activity,
Mineralocorticoids,
Iontophoresis
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