Antiretroviral agents and acid-base balance at delivery of the neonate



Título del documento: Antiretroviral agents and acid-base balance at delivery of the neonate
Revista: Brazilian journal of medical and biological research
Base de datos: PERIÓDICA
Número de sistema: 000350920
ISSN: 0100-879X
Autors: 1
1
2
3
1
1
1
3
Institucions: 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
2Universidade Federal de Santa Maria, Centro de Ciencias de Saude, Santa Maria, Rio Grande do Sul. Brasil
3London School of Hygiene and Tropical Medicine, Infectious Disease Epidemiology Unit, Londres. Reino Unido
Any:
Període: Jul
Volum: 40
Número: 7
Paginació: 957-961
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups: ZDV group, born to mothers taking zidovudine (N = 20), triple therapy (TT) group, born to mothers taking zidovudine + lamivudine + nelfinavir (N = 25), and control group (N = 12), born to uninfected mothers. Umbilical cord blood was used to determine umbilical artery gases. A test was performed to calculate the sample by comparing means by the unpaired one-tailed t-test, with a = 0.05 and ß = 20%, indicating the need for a sample of 18 newborn infants for the study groups to detect differences higher than 20%. The control and ARV groups were similar in gestational age, birth weight, and Apgar scores. Values of pH, pCO2, bicarbonate, and base excess in cord arterial blood obtained at delivery from the newborns exposed to TT were 7.23, 43.2 mmHg, 19.5 mEq/L, and -8.5 nmol/L, respectively, with no significant difference compared to the control and ZDV groups. We conclude that intrauterine exposure to ARV is not associated with a pathological decrease in umbilical arterial pH or base excess. While our data are reassuring, follow-up is still limited and needs to be continued into adulthood because of the possible potential for adverse effects of triple antiretroviral agents
Disciplines Medicina
Paraules clau: Pediatría,
Embarazo,
Antirretrovirales,
Toxicidad,
Recién nacidos,
Arteria umbilical,
pH
Keyword: Medicine,
Pediatrics,
Pregnancy,
Antiretrovirals,
Toxicity,
Newborn,
Umbilical artery,
pH
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