| Revista: | Brazilian journal of chemical engineering |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000308612 |
| ISSN: | 0104-6632 |
| Autors: | Silva, A.S1 Cruz, A.J.G Araujo, M.L.G.C2 Hokka, C.O |
| Institucions: | 1Universidade Federal de Sao Carlos, Departamento de Engenharia Quimica, Sao Carlos, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Quimica, Araraquara, Sao Paulo. Brasil |
| Any: | 1998 |
| Període: | Dic |
| Volum: | 15 |
| Número: | 4 |
| Paginació: | 320-325 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cephalosporin C, a b-lactam antibiotic, is the starting molecule for industrial production of semi-synthetic cephalosporins. The bioprocess for its production is carried out in batch stirred and aerated tank reactors utilizing strains of the filamentous fungus Cephalosporium acremonium. In this work a comparison was made between the processes of production of cephalosporin C in a conventional batch bioreactor, with synthetic medium containing glucose and sucrose, and in a fed-batch reactor at several flowrates of supplementary medium containing invert sucrose. In general, the fed-batch process was shown to be more efficient than the conventional batch one, and the process in which the lowest supplementation flowrate was used presented an antibiotic production significantly higher than those obtained under the other conditions |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Biotecnología, Cefalosporina C, Azúcares invertidos, Proceso discontinuo, Cephalosporium acremonium |
| Keyword: | Chemistry, Medicinal chemistry, Biotechnology, Cephalosporin C, Inverted sugars, Fed batch, Cephalosporium acremonium |
| Text complet: | Texto completo (Ver HTML) |
