| Revista: | Brazilian journal of chemical engineering |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000308978 |
| ISSN: | 0104-6632 |
| Autors: | Santos, M.A.G1 Veredas, V Silva-Junior, I.J Correia, C.R.D2 Furlan, L. T3 Santana, C. C |
| Institucions: | 1Universidade Estadual de Campinas, Faculdade de Engenharia Quimica, Campinas, Sao Paulo. Brasil 2Universidade Estadual de Campinas, Instituto de Quimica, Campinas, Sao Paulo. Brasil 3Petroleo Brasileiro S.A., Rio de Janeiro. Brasil |
| Any: | 2004 |
| Període: | Ene |
| Volum: | 21 |
| Número: | 1 |
| Paginació: | 127-136 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Due to this fact, fully recognized today, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture whenever a chiral compound is involved. The simulated moving bed (SMB) is a chromatographic process that, unlike traditional HPLC systems, operates continuously without losing the enantiomeric purity of the outlet streams. The present work describes the enantioseparation of the anesthetic ketamine in a semipreparative-scale SMB unit. The chiral stationary phase employed was the microcrystalline cellulose triacetate. The outlet streams were analyzed by an on-line system, composed by an UV/VIS meter and a polarimeter, and also by HPLC. The analysis indicated purity values up to 100% for the stream of interest and up to 97.7% for the other stream |
| Disciplines | Química |
| Paraules clau: | Ingeniería química, Mezclas racémicas, Enantiómeros, Cromatografía, Ketamina |
| Keyword: | Chemistry, Chemical engineering, Racemic mixtures, Enantiomers, Chromatography, Ketamine |
| Text complet: | Texto completo (Ver HTML) |
