Revista: | Brazilian archives of biology and technology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000388223 |
ISSN: | 1516-8913 |
Autors: | Maia, Rafael Trindade1 Nadvorny, Daniela2 |
Institucions: | 1Universidade Federal de Pernambuco, Departamento de Zoologia, Recife, Pernambuco. Brasil 2Universidade Federal de Pernambuco, Departamento de Quimica Fundamental, Recife, Pernambuco. Brasil |
Any: | 2014 |
Període: | Sep-Oct |
Volum: | 57 |
Número: | 5 |
Paginació: | 689-694 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Nota breve o noticia |
Enfoque: | Experimental |
Resumen en inglés | The aim of this study was to develop a theoretical model using Anopheles gambiae GSTE2 structure as template for Aedes aegypti GSTE2 by homology modeling Docking simulations were performed for both the enzymes against usnic acid in neutral and anionic forms. Ramachandran plot revealed that 93.9% of the GSTE2 model residues were located on most favored regions. Model evaluation was made by the ANOLEA and GROMOS analysis. Docking results indicated that the enzymes were able to form glutathione-conjugate with usnic acid in both the forms (anionic and neutral) |
Disciplines | Biología, Química |
Paraules clau: | Insectos, Bioquímica, Mosquitos, Resistencia a insecticidas, Modelos moleculares, Glutatión S-transferasa, Acido úsnico, Anopheles gambiae, Aedes aegypti, Diptera |
Keyword: | Biology, Chemistry, Insects, Biochemistry, Mosquitoes, Insecticides resistance, Molecular models, Glutathione S-transferase, Usnic acid, Anopheles gambiae, Aedes aegypti, Diptera |
Text complet: | Texto completo (Ver HTML) |