| Revista: | Brazilian archives of biology and technology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000372627 |
| ISSN: | 1516-8913 |
| Autors: | Telles, Thalita Costa1 Michel, Ana Flavia Ribeiro Machado1 Lucia, Maria2 Melo, Bruno Martins3 Bicalho, Adriane Costa-Val Pimenta1 Ocarino, Natalia de Melo1 Melo, Marilia Martins1 |
| Institucions: | 1Universidade Federal de Minas Gerais, Escola de Veterinaria, Belo Horizonte, Minas Gerais. Brasil 2Universidade Jose do Rosario Vellano, Departamento de Biologia, Alfenas, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Minas Gerais. Brasil |
| Any: | 2014 |
| Període: | Ene-Feb |
| Volum: | 57 |
| Número: | 1 |
| Paginació: | 29-36 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | The aim of this work was to evaluate the mesenchymal stem cells treatment of rats with myonecrosis caused by Rhinocerophis alternatus venom through acute phase proteins (APP) profile. The animals were distributed into three experimental groups (G1, G2 and G3). G1 and G2 were inoculated with 120 μg of R. alternatus venom diluted in 200 μL of ultra-pure water in gastrocnemic muscle, while G3 received 200 μL of ultra-pure water. Three days after, G1 was treated with 5 X 106 MSC diluted in PBS and G2 and G3 only with PBS. Each three days after the treatments (3rd, 6th, 9th, 12th 15th days), blood of five animals in each group was collected in order to evaluate the APP. A decrease (P<0.05) in α2-globulin fraction was observed in G1 on the 6th day. In G1 and G2, a raise (P<0.05) was observed in β globulin, a common occurrence in the late phases of inflammatory process, although no significant difference was observed between them. Concerning gamma globulins levels, on the 6th day after the treatments, in G1 and G2 groups, increase in the levels was observed. These data showed that the MSC treatment after bothropic envenomation in the rats caused alteration in APP |
| Disciplines | Biología, Química, Medicina |
| Paraules clau: | Biología celular, Bioquímica, Terapéutica y rehabilitación, Veneno, Rhinocerophis alternatus, Ratas, Células madre mesenquimales, Proteínas inflamatorias |
| Keyword: | Biology, Chemistry, Medicine, Cell biology, Biochemistry, Therapeutics and rehabilitation, Venom, Rhinocerophis alternatus, Rats, Mesenquimal stem cell, Inflammatory proteins |
| Text complet: | Texto completo (Ver PDF) |
