Revista: | Brazilian archives of biology and technology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000373454 |
ISSN: | 1516-8913 |
Autors: | Maia-Filho, Antonio Luiz Martins1 Amaral, Fabricio Pires de Moura do2 Martin, Airton Abrahao3 Soares, Luís Eduardo Silva3 |
Institucions: | 1Faculdade Santo Agostinho, Laboratorio de Fisiologia, Teresina, Piaui. Brasil 2Faculdade Diferencial, Laboratorio de Anatomia, Teresina, Piaui. Brasil 3Universidade do Vale do Paraiba, Faculdade de Ciencias da Saude, Sao Jose dos Campos, Sao Paulo. Brasil |
Any: | 2014 |
Període: | May-Jun |
Volum: | 57 |
Número: | 3 |
Paginació: | 334-339 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | The aim of this work was to study the influence of uncoated and apatite-coated Al2O3 implants on bone regeneration after 30 days of surgery in New Zealand white rabbits. Twelve samples of Al2O3 implants were prepared and half of them (n = 6) were apatite-coated by the modified biomimetic method. Three experimental groups were tested as Group C - control, surgery procedure without cerami c implant, Group Ce - uncoated Al 2O3 implants (n = 6) and Group CeHA - apatite-coated Al2O3 implants (n = 6). The mineralization of the Al2O3 implants was analyzed in bone fragments using FT-Raman spectroscopy. Raman peaks at 959 cm-1 and 2940 cm-1 evaluated the inorganic and organic bone content, respectively. In vivo citotoxicity was analyzed using micronucleus test. Inorganic and organic content were higher in CeHA samples than in Ce and C (CeHA > Ce > C). FT-Raman spectroscopy showed that the higher the deposition of the organic matrix, more mineralization occurred. The micronucleus test showed that the uncoated and apatite-coated Al2O3 implants were non-cytotoxic and safe to in vivo applications |
Disciplines | Medicina veterinaria y zootecnia |
Paraules clau: | Medicina veterinaria, Regeneración ósea, Espuma metálica, Alúmina, Apatita, Conejos, Prueba de micronúcleos, Citotoxicidad |
Keyword: | Veterinary medicine and animal husbandry, Veterinary medicine, Bone regeneration, Metallic foam, Alumina, Apatite, Rabbits, Micronucleus test, Cytotoxicity |
Text complet: | Texto completo (Ver HTML) |