Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats
Título del documento: Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats
Revista: Biocell
Base de datos: PERIÓDICA
Número de sistema: 000343486
ISSN: 0327-9545
Autores: 1
1
Instituciones: 1All India Institute of Medical Sciences, Department of Pharmacology, Ansari Nagar, New Delhi. India
Año:
Volumen: 35
Número: 3
Paginación: 63-69
País: Argentina
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in diabetic rats produced anti-hyperglycemic effect that was comparable to that of glibenclamide (10 mg/kg). Unlike glibenclamide, the aqueous suspension did not increase the serum insulin levels in diabetic rats. However, it produced a marked reduction in the levels of urinary glucose and protein and normalized the renal tissue levels of thiobarbituric acid-reactive substances (TBARS) and glutathione (GSH) in diabetic rats and the effect was comparable to that of glibenclamide. The protection afforded by the aqueous suspension was also evident from the histological analysis of the renal tissue. Our study shows that by exhibiting antioxidant and anti-hyperglycemic property the aqueous suspension of dried latex of C. procera affords protection against the complications associated with diabetes
Disciplinas: Medicina
Palabras clave: Medicina experimental,
Metabolismo y nutrición,
Plantas medicinales,
Diabetes,
Antioxidantes,
Daño renal,
Látex,
Calotropis procera
Keyword: Medicine,
Experimental medicine,
Metabolism and nutrition,
Medicinal plants,
Diabetes,
Antioxidants,
Renal damage,
Latex,
Calotropis procera
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