| Revista: | Archives of clinical psychiatry |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000407879 |
| Autores: | Yildiz, Mesut1 Celikel, Feryal Cam2 Ates, Omer1 Taycan, Serap Erdogan3 Benli, Ismail1 Demir, Osman1 |
| Instituciones: | 1Gaziosmanpasa University, Faculty of Medicine, Tokat. Turquía 2Isik University, Institute of Social Sciences, Estambul. Turquía 3Haydarpasa Numune Training and Research Hospital, Psychiatry Department, Estambul. Turquía |
| Año: | 2017 |
| Periodo: | May-Jun |
| Volumen: | 44 |
| Número: | 3 |
| Paginación: | 73-76 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Psiquiatría, Bioquímica, Depresión mayor, Trastorno afectivo bipolar, Polimorfismo genético, Paraoxonasa |
| Keyword: | Medicine, Neurology, Psychiatry, Biochemistry, Major depression, Bipolar affective disorder, Genetic polymorphism, Paraoxonase |
| Texto completo: | Texto completo (Ver HTML) |
