| Revista: | Archives of clinical psychiatry |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000419340 |
| Autors: | Santos, Rafael G. Dos1 Sanches, Rafael Faria1 Osorio, Flavia de Lima1 Hallak, Jaime E.C1 |
| Institucions: | 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Any: | 2018 |
| Període: | Ene-Feb |
| Volum: | 45 |
| Número: | 1 |
| Paginació: | 22-24 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Ayahuasca is a botanical hallucinogenic preparation traditionally used by indigenous populations of Northwestern Amazonian countries for ritual and therapeutic purposes. It is rich in β-carboline alkaloids and N,N-dimethyltryptamine (DMT). Preclinical, observational, and experimental studies suggest that ayahuasca and its alkaloids have anxiolytic and antidepressive effects. We recently reported in an open-label trial that ayahuasca administration was associated with significant decreases in depression symptoms for 2-3 weeks after the experimental session in 17 patients with treatment-resistant major depressive disorder. Objectives: To investigate if the experiment had any long-lasting effects on patients Methods: Eight patients were interviewed 4 to 7 years after ayahuasca intake. Results: Our results suggest that ayahuasca was well tolerated and that symptom reductions were limited to a few weeks. Importantly, most patients believed that the experience was among the most important of their lives, even 4-7 years later. Discussion: To the best of our knowledge, this is the first long-term follow-up of a clinical sample that participated in an ayahuasca trial. Further studies with different and repeated dosing should be designed to further explore the antidepressive and anxiolytic effects of ayahuasca |
| Disciplines | Medicina, Química |
| Paraules clau: | Psiquiatría, Fitoquímica, Farmacología, Alucinógenos, Drogas psicodélicas, Depresión, Ayahuasca |
| Keyword: | Psychiatry, Phytochemistry, Pharmacology, Hallucinogens, Psychedelic drugs, Depression, Ayahuasca |
| Text complet: | Texto completo (Ver PDF) |
