Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review

Título del documento: Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000419361
Autors: 1
Institucions: 1Administracao Regional de Saude de Lisboa e Vale do Tejo, Unidade de Saude Familiar, Malveira. Brasil
Període: Mar-Abr
Volum: 45
Número: 2
Paginació: 38-40
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Lithium is often used in bipolar disorder and occasionally in unipolar depression. Non-steroidal anti-inflammatory drugs (NSAIDs) and diuretics are frequently prescribed and their interaction with lithium is based mainly in few small studies. Objectives: Conduct a review, identify different interaction patterns and discuss treatment options. Methods: Three searches were made in PubMed in January 2016: 1) using the keywords “lithium” [and] “non-steroidal anti-inflammatory”; 2) using the keywords “lithium” [and] “diuretics” and the filter “title/abstract”; 3) using the terms “lithium” [and] “toxicity” and the filters “title” [and] “review”. From the 293 remaining articles, 10 were selected. Another search in was made, using the term “lítio” and the filter “Psiquiatria”. Two articles were selected from the initial 53. Six textbooks were added to expand the evidence, achieving a total of 18 references. Results: The majority of NSAIDs and diuretics rises lithium levels, specially thiazides. However, some show great variability or no interaction at all, and others even decrease lithium levels. Discussion: Lower-doses, shorter durations, lithium adjustments and levels' follow-ups are recommended, especially in elderly and multiple co-morbid patients
Disciplines Medicina
Paraules clau: Psiquiatría,
Trastorno bipolar,
Antiinflamatorios no esteroideos,
Interacciones medicamentosas
Keyword: Psychiatry,
Bipolar disorder,
Non steroidal antinflammatory drugs,
Drug interaction
Text complet: Texto completo (Ver HTML)