Efficacy of single dose antihistamine vs. single dose valerian-hops in subjective sleep measures among war refugees: a comparison trial
Título del documento: Efficacy of single dose antihistamine vs. single dose valerian-hops in subjective sleep measures among war refugees: a comparison trial
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000407885
Autores: 1
1
2
1
3
4
Instituciones: 1American University of Madaba, Madaba. Jordania
2Jordan University of Science and Technology, Irbid. Jordania
3Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Estados Unidos de América
4Royal Medical Services, King Hussain Hospital, Ammán. Jordania
Año:
Periodo: Mar-Abr
Volumen: 44
Número: 2
Paginación: 35-39
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Many sedatives and anxiolytics are used in single dose or chronically to aid sleep. Clinically important sedatives include valerian-hops and antihistamines as they are used over the counter and are highly accessible and safe agents. Objectives To evaluate and compare a single dose of chlorpheniramine versus valerian-hops combination in modulating subjective sleep measures in insomniac war refugees. Methods Insomnia among refugees was screened using the Insomnia Severity Index (ISI). Insomniac subjects were randomized to received a single dose valerian-hops (320/80 mg) (n = 65), or chlorpheneramine (4 mg) (n = 50) or placebo (n = 76) two hours prior sleeping. Participants were instructed to complete Leeds Sleep Evaluation Questionnaire (LSEQ), visual analogue scales of anxiety and sedation. Also sleep latency, total hours slept and self-rated improvement were obtained. Results Almost 75% of screened refugees had insomnia. Chlorpheneramine reduced sleep latency and anxiety significantly, however it resulted in poor sleep quality. Valerian-hops group showed marked anxiolysis one hour after dosing, a sleep quality similar to placebo and better than chlorpheneramine, and better alertness compared to placebo. Participants satisfaction was higher with chlorpheneramine and there was no difference in the total hours slept. Discussion Valerian-hops combination may provide better sleep quality than antihistamines
Disciplinas: Medicina
Palabras clave: Farmacología,
Psiquiatría,
Insomnio,
Sedantes,
Ansiolíticos,
Antihistamínicos,
Valeriana,
Calidad del sueño
Keyword: Medicine,
Pharmacology,
Psychiatry,
Insomnia,
Sedatives,
Anxiolytic agents,
Antihistaminics,
Valeriane,
Sleep quality
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