| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411377 |
| ISSN: | 1665-2681 |
| Autors: | Wu, Yichen1 You, Shaoli1 Zang, Hong1 Liu, Hongling1 Mao, Yuanli2 Mao, Panyong3 Zhu, Bing1 Xu, Jun2 Xie, Guoming3 Guo, Jingxia2 Li, Dongze1 Zhihong Wan1 Xin, Shaojie1 |
| Institucions: | 1302 Military Hospital of China, Liver Failure Treatment and Research Center, Beijing. China 2302 Military Hospital of China, Clinical Laboratory Center, Beijing. China 3302 Military Hospital of China, Research and Technology Service Center, Beijing. China |
| Any: | 2015 |
| Període: | Mar-Abr |
| Volum: | 14 |
| Número: | 2 |
| Paginació: | 218-224 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | To investigate thyroid function in patients with acute-on-chronic liver failure (ACLF) caused by hepatitis B virus infection and to determine whether thyroid hormone levels can be used as prognostic markers for assessing severity and prognosis of ACLF patients. We enrolled 75 patients with ACLF and70 patients with chronic hepatitis B (CHB).Continual serum samples were collected during hospitalization from the ACLF patients. The serum thyroid hormone levels (triiodothyronine [T3], thyroxine [T4], free (F)-T3, FT4, and thyroid stimulation hormone [TSH]) were measured by chemiluminescence. The Model for End-stage Liver Disease (MELD) score was used to assess severity. Results. ACLF patients showed significantly (p < 0.001) lower values of serum T3, T4, FT3/FT4 and TSH than CHB patients. The T3, T4, and TSH levels in ACLF patients were negatively correlated with the MELD score (T3: r = -0.495, p < 0.001; T4: r = -0.281, p < 0.001; TSH: r = -0.498, p < 0.001), suggesting that serum thyroid hormone levels reflect disease severity. At 1 year, 31 patients died. The T3 (p = 0.016), T4 (p = 0.008), and TSH (p = 0.003) levels in non-survivors were significantly lower than in survivors. The serum TSH level was a significant factor for predicting mortality in ACLF patients (optimal cutoff value = 0.38 IU/mL). The cumulative survival rate was decreased significantly when the serum TSH level was < 0.38 IU/mL (39.2%, p < 0.001). Conclusion. Serum TSH level may be a useful indicator for assessing severity and prognosis in ACLF patients |
| Disciplines | Medicina |
| Paraules clau: | Diagnóstico, Gastroenterología, Hepatitis B, Falla hepática aguda, Hormonas tiroideas, Factores pronósticos |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Hepatitis B, Acute liver failure, Thyroid hormones, Prognostic factors |
| Text complet: | Texto completo (Ver PDF) |
