The epidemiologic burden of hepatitis C virus infection in Latin America



Título del documento: The epidemiologic burden of hepatitis C virus infection in Latin America
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000419051
ISSN: 1665-2681
Autors: 1
1
2
2
3
4

1
Institucions: 1Oxford Outcomes Ltd., Vancouver, Columbia Británica. Canadá
2Bristol-Myers Squibb, Nueva York. Estados Unidos de América
3University of British Columbia, Vancouver, Columbia Británica. Canadá
4Instituto Politécnico Nacional, Centro de Investigación y de Estudios Avanzados, México, Distrito Federal. México
Any:
Període: Sep-Oct
Volum: 11
Número: 5
Paginació: 623-635
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Chronic infection with hepatitis C virus (HCV) is a major and growing public health concern worldwide, including in Latin America. With more efficacious therapies becoming available, decision-makers will require accurate estimates of disease prevalence to assess the potential impact of new treatments. However, few estimates of the epidemiologic burden, either overall or by country, are available for Latin America; and the potential impact of currently-available treatments on the epidemiologic burden of HCV in Latin America has not been assessed. To address this, we systematically reviewed twenty-five articles presenting population-based estimates of HCV prevalence from general population or blood donor samples, and supplemented those with publically-available data, to estimate the total number of persons infected with HCV in Latin America at 7.8 million (2010). Of these, over 4.6 million would be expected to have genotype 1 chronic HCV, based on published data on the risk of progression to chronic disease and the HCV genotype distribution of Latin America. Finally, we calculated that between 1.6 and 2.3 million persons with genotype 1 chronic HCV would potentially benefit from current treatments, based on published estimates of genotypespecific treatment responsiveness. In conclusion, these estimates demonstrate the substantial present epidemiologic burden of HCV, and quantify the impending societal and clinical burden from untreated HCV in Latin America
Disciplines Medicina
Paraules clau: Gastroenterología,
Salud pública,
Virus de la hepatitis C,
Hepatitis crónica,
Epidemiología,
Prevalencia,
América Latina
Keyword: Gastroenterology,
Public health,
Hepatitis C virus,
Chronic hepatitis,
Epidemiology,
Prevalence,
Latin America
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