| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418124 |
| ISSN: | 1665-2681 |
| Autors: | Hazra, Bibhabasu1 Sarkar, Rhitajit1 Mandal, Nripendranath1 |
| Institucions: | 1Bose Institute, Division of Molecular Medicine, Calcuta, Bengala Occidental. India |
| Any: | 2013 |
| Període: | Feb |
| Volum: | 12 |
| Número: | 1 |
| Paginació: | 123-129 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | The present study was designed to evaluate the ameliorating effect of 70% methanol extract of Spondias pinnata (SPME) on iron overload induced liver injury. Iron overload was induced by intraperitoneal administration of iron-dextran into mice and resulting liver damage was manifested by significant rise in serum enzyme markers (ALT, AST, ALP and bilirubin) and reduction in liver antioxidants (SOD, CAT, GST and GSH). Hepatic iron, serum ferritin, lipid peroxidation, protein carbonyl and hydroxyproline contents were measured in response to the oral administration of SPME of different doses (50, 100 and 200 mg/kg body weight). In order to determine the efficiency as iron chelating drug, the release of iron from ferritin by SPME was further studied. Enhanced levels of antioxidant enzymes were detected in SPME treated mice. SPME produced a dose dependent inhibition of lipid peroxidation, protein oxidation, liver fibrosis; and levels of serum enzyme markers and ferritin were also reduced dose dependently. The liver iron content was also found to be less in SPME treated group compared to control group. The reductive release of ferritin iron was augmented significantly after dose dependent addition of SPME. The ameliorating effect of SPME on damaged liver was furthermore supported by the histopathological studies that showed improved histological appearances. In conclusion, the present results demonstrate the hepatoprotective efficiency of SPME in iron intoxicated mice, and hence possibly useful as iron chelating drug for iron overload diseases |
| Disciplines | Medicina |
| Paraules clau: | Gastroenterología, Terapéutica y rehabilitación, Spondias pinnata, Sobrecarga de hierro, Lesiones hepáticas, Hepatotoxicidad, Peroxidación lipídica, Enzimas antioxidantes, Ferritina, Hidroxiprolina |
| Keyword: | Gastroenterology, Therapeutics and rehabilitation, Spondias pinnata, Iron overload, Liver injury, Hepatotoxicity, Lipid peroxidation, Antioxidant enzymes, Ferritin, Hydroxyproline |
| Text complet: | Texto completo (Ver PDF) |
