Revista: | Annals of hepatology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000419053 |
ISSN: | 1665-2681 |
Autors: | Ladero, José M1 Cárdenas, María C1 Ortega, Luis1 González Pino, Andrea1 Cuenca, Francisca1 Morales, César1 Lee-Brunner, Anna1 |
Institucions: | 1Hospital Clínico San Carlos, Instituto de Investigación Sanitaria, Madrid. España |
Any: | 2012 |
Període: | Sep-Oct |
Volum: | 11 |
Número: | 5 |
Paginació: | 648-651 |
País: | México |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Serum levels of cystatin C, an endogenous inhibitor of cysteine proteases, provide an alternative method to creatinine-based criteria for measuring glomerular filtration rate. Preliminary data suggested that serum cystatin C levels parallel with the stage of liver fibrosis in chronic liver disorders. Our aim has been to evaluate the possible role of serum cystatin C as a marker of liver fibrosis in hepatitis C virus (HCV)-induced chronic liver disease. Material and methods. 100 consecutive patients (56 men, mean age 51.2 ± 9.5 yrs) with HCV-induced chronic liver disease, scheduled for their first liver biopsy and naïve for antiviral therapy were included. Liver fibrosis was evaluated with the METAVIR score. Serum cystatin C and standard laboratory tests were measured simultaneously. Patients with ethanol abuse (> 50 g/day), HBV or HIV coinfection or plasma creatinine ≥ 1.20 mg/dL were excluded. In addition, a second group of 16 patients fulfilling the same requisites and diagnosed with HCV-induced compensated cirrhosis by clinical evidence of portal hypertension was included. Results. Serum cystatin C levels significantly increase from F0 to F2 fibrosis stages, remained stable in F3 and F4 stages and increased again in the group of non-biopsied compensated cirrhosis. Serum cystatin C levels were higher in patients with moderate-advanced necroinflammation in the liver biopsy. Conclusion. Serum cystatin C level may reflect current fibrogenic and necroinflammatory activities in chronic HCV-induced liver disease with normal renal function but can not be considered as a non-invasive marker of liver fibrosis |
Disciplines | Medicina |
Paraules clau: | Gastroenterología, Diagnóstico, Hepatitis crónica, Virus de la hepatitis C, Fibrosis hepática, Marcadores diagnósticos, Cistatina C |
Keyword: | Gastroenterology, Diagnosis, Chronic hepatitis, Hepatitis C virus, Liver fibrosis, Diagnostic markers, Cystatin C |
Text complet: | Texto completo (Ver PDF) |