| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000412988 |
| ISSN: | 1665-2681 |
| Autors: | Kanter, Clara T.M.M. de1 Luin, Matthijs van1 Solas, Caroline2 Burger, David M1 Vrolijk, Jan Maarten3 |
| Institucions: | 1Radboud University, medical center, Nijmegen, Gelderland. Países Bajos 2Rijnstate Hospital, Department of Gastroenterology and Hepatology, Arnhem. Países Bajos |
| Any: | 2014 |
| Període: | Jul-Ago |
| Volum: | 13 |
| Número: | 4 |
| Paginació: | 452-455 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient’s renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions |
| Disciplines | Medicina |
| Paraules clau: | Farmacología, Gastroenterología, Hepatitis C, Rabdomiólisis, Interacción medicamentosa, Inhibidores de la proteasa, Efectos adversos, Telaprevir, Estatinas |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Hepatitis C, Rhabdomyolysis, Drug interaction, Protease inhibitors, Adverse effects, Telaprevir, Statins |
| Text complet: | Texto completo (Ver PDF) |
