| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000407165 |
| ISSN: | 1665-2681 |
| Autors: | Lieveld, Faydra I1 Swaans, Niels2 Newsum, Astrid M3 Ho, Cynthia K.Y3 Schinkel, Janke3 Molenkamp, Richard3 van der Meer, Jan T.M4 Arends, Joop E5 Hoepelman, Andy I.M5 Wensing, Anne M.J6 Siersema, Peter D1 van Erpecum, Karel J1 Boland, Greet J1 |
| Institucions: | 1University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht. Países Bajos 2University Medical Center Utrecht, Department of Medical Microbiology, Utrecht. Países Bajos 3Academic Medical Center, Department of Medical Microbiology, Amsterdam. Países Bajos 4Academic Medical Center, Department of Internal Medicine and Infectious Diseases, Amsterdam. Países Bajos 5University Medical Center Utrecht, Department of Internal Medicine and Infectious Diseases, Utrecht. Países Bajos 6University Medical Center Utrecht, Department of Medical Microbiology, Utrecht. Países Bajos |
| Any: | 2016 |
| Període: | Sep-Oct |
| Volum: | 15 |
| Número: | 5 |
| Paginació: | 696-704 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Resistanc Background and aim. e-associated variants (RAVs) on the NS3 region of the hepatitis C virus (HCV) may be relevant for antiviral therapy, but data in human immunodeficiency virus (HIV) coinfected patients are scarce. We assessed frequencies of NS3 RAVs in patients infected with HCV genotype 1a with or without HIV coinfection. Material and methods. Material and methods. HCV NS3 amino Material and methods. acids 1-181 were sequenced by the Sanger method and analyzed for RAVs. RAVs and their distribution between HCV genotype 1a clade I and II viruses were compared between HIV-infected versus HIV-uninfected patients. Results. Results. 148 Results. samples were available (n = 68 HIV and n = 80 non-HIV). Relative frequency of clade I and clade II was significantly different between HIV (85% and 15%) and non-HIV groups (49% and 51%). Overall, HIV infected patients exhibited significantly lower prevalence of RAVs than HIV-uninfected patients (62% vs. 79%, p = 0.03). However, Q80K prevalence was significantly higher in HIV-infected subjects (50% vs. 24%, p = 0.001), whereas prevalence of S122D/G/N/S (2% vs. 16%, p = 0.002) and N174G/N/S (10% vs. 55%, p < 0.0001) polymorphisms were significantly lower. Q80K was found exclusively in clade I viruses. S122 (3% vs. 22%, p=0.001) and N174 (13% vs. 75%, p<0.0001) polymorphisms had significantly lower prevalence in clade I than clade II viruses. Conclusions. Conclusions. In Conclusions. the Netherlands, prevalence of clade I viruses and Q80K was significantly higher in HCV genotype 1a infected patients with HIV coinfection than in those without HIV coinfection. Prevalence of N174 and S122 polymorphisms was significantly higher in clade II than clade I viruses |
| Disciplines | Medicina |
| Paraules clau: | Gastroenterología, Microbiología, Hepatitis C, Virus de la hepatitis C, Resistencia a fármacos, Antivirales, Polimorfismo genético, VIH |
| Keyword: | Medicine, Gastroenterology, Microbiology, Hepatitis C, Hepatitis C virus, Drug resistance, Antiviral agents, Genetic polymorphism, HIV |
| Text complet: | Texto completo (Ver PDF) |
