Primary hepatic neuroendocrine tumour requiring live donor liver transplantation: case report and concise review



Título del documento: Primary hepatic neuroendocrine tumour requiring live donor liver transplantation: case report and concise review
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000419067
ISSN: 1665-2681
Autors: 1
2
3
2
2
1
Institucions: 1Vancouver General Hospital, Department of Pathology and Laboratory Medicine, Vancouver, Columbia Británica. Canadá
2Vancouver General Hospital, Division of Gastroenterology, Vancouver, Columbia Británica. Canadá
3Vancouver General Hospital, Department of Surgery, Vancouver, Columbia Británica. Canadá
Any:
Període: Sep-Oct
Volum: 11
Número: 5
Paginació: 715-720
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés Primary hepatic neuroendocrine tumours are rare tumours effecting relatively young patients. As metastatic neuroendocrine tumours to the liver are much more common, extensive investigations are crucial to exclude a primary tumour elsewhere. We report a case of a 27 year old woman who presented with fatigue, increased abdominal girth and feeling of early satiety and bloating. Extensive work up failed to show tumour at another primary site. Hepatic artery embolization showed no effect, so the patient underwent total hepatectomy and live-donor liver transplant. Grossly the tumour measured 27 cm. Microscopic examination showed bland, monomorphic cells growing in tubuloglandular and trabecular growth patterns. Cells were positive for neuroendocrine (synaptophysin, chromogranin, CD56) and epithelial markers (MOC31, CK7, CK19). Cytoplasmic dense neurosecretory vesicles were seen on ultrastructural examination. Based on the Ki-67 rate, mitotic count, lack of marked nuclear atypia and absence of necrosis, a diagnosis of primary neuroendocrine grade 2 was conferred
Disciplines Medicina
Paraules clau: Gastroenterología,
Oncología,
Hígado,
Tumores neuroendócrinos,
Trasplante de hígado,
Donadores vivos
Keyword: Gastroenterology,
Oncology,
Liver,
Neuroendocrine tumors,
Liver transplantation,
Living donors
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