| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000412947 |
| ISSN: | 1665-2681 |
| Autors: | Lei Jianyong1 Zhong Jinjing1 Wang Wentao1 Yan Lunan1 Zhou Qiao1 Li Bo1 Wen Tianfu1 Xu Minqing1 Yang Jiaying1 Wei Yongang1 |
| Institucions: | 1Sichuan University, West China Hospital, Chengdu, Sichuan. China |
| Any: | 2014 |
| Període: | Jul-Ago |
| Volum: | 13 |
| Número: | 4 |
| Paginació: | 394-402 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Estadística o encuesta |
| Enfoque: | Analítico |
| Resumen en inglés | The effect of preoperative transcatheter arterial chemoembolization (TACE) on the short- and long-term outcome of resectable hepatocellular carcinoma (HCC) is controversial. We conducted a retrospective evaluation of this aspect using data from our center. Material and methods. A total of 656 consecutive patients who underwent curative resection of HCC were divided into two groups based on the preoperative TACE: the liver resection (LR) group (405 cases) and the TACE-LR group (183 cases). Overall and disease-free survival curves were constructed using the Kaplan-Meier method and compared with the log-rank test. The significance of differences in survival was tested using a log-rank test. Univariate and multivariate analyses were used to identify the factors that best predicted overall survival or tumorfree survival. Results. Although the cost of LR showed no difference between groups, the overall cost was significantly higher in the combined group than in the LR group (P < 0.001). The complication rate after resection was also comparable between the two groups. In regard to long-term outcome, the 1-, 3-, and 5-year overall survival rates were 83.7, 68.9 and 57.5%, respectively, after direct liver resection and 80.9, 65.0 and 54.1%, respectively, after combined TACE and resection (P = 0.739). The 1-, 3-, and 5-year recurrence-free survival rates were also comparable between two groups (P = 0.205). Both univariate analysis and multivariate analysis showed that macro-vascular invasion was the factor that best predicted overall survival or tumor-free survival rate. Conclusion. Preoperative TACE has comparable intraoperative and short-term outcomes but more overall cost due to repeated TACE, and the procedure did not significantly improve the overall or tumor-free survival rate. Preoperative TACE should not, therefore, be recommended as a routine procedure before resection for resectable HCCs particularly in cases due to.. |
| Disciplines | Medicina |
| Paraules clau: | Cirugía, Gastroenterología, Hígado, Resección, Preoperatorio, Resultados, Sobrevivencia, Quimioembolización, Carcinoma hepatocelular |
| Keyword: | Medicine, Gastroenterology, Surgery, Liver, Resection, Preoperative period, Results, Survival, Chemoembolization, Hepatocellular carcinoma |
| Text complet: | Texto completo (Ver PDF) |
