| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411829 |
| ISSN: | 1665-2681 |
| Autors: | Manzano Robleda, María del Carmen1 Barranco Fragoso, Beatriz2 Uribe, Misael1 Méndez Sánchez, Nahum1 |
| Institucions: | 1Fundación Clínica Médica Sur, Unidad de Investigación de Hígado, México, Distrito Federal. México 2Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, México, Distrito Federal. México |
| Any: | 2015 |
| Període: | Ene-Feb |
| Volum: | 14 |
| Número: | 1 |
| Paginació: | 20-27 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Portal vein thrombosis (PVT) is one of the most common vascular disorders of the liver with significant morbidity and mortality. Large cohort studies have reported a global prevalence of 1%, but in some risk groups it can be up to 26%. Causes of PVT are cirrhosis, hepatobiliary malignancy, abdominal infectious or inflammatory diseases, and myeloproliferative disorders. Most patients with PVT have a general risk factor. The natural history of PVT results in portal hypertension leading to splenomegaly and the formation of portosystemic collateral blood vessels and esophageal, gastric, duodenal, and jejunal varices. Diagnosis of PVT is made by imaging, mainly Doppler ultrasonography. According to its time of development, localization, pathophysiology, and evolution, PVT should be classified in every patient. Some clinical features such as cirrhosis, hepatocellular carcinoma, and hepatic transplantation are areas of special interest and are discussed in this review. The goal of treatment of acute PVT is to reconstruct the blocked veins. Endoscopic variceal ligation is safe and highly effective in patients with variceal bleeding caused by chronic PVT. In conclusion, PVT is the most common cause of vascular disease of the liver and its prevalence has being increasing, especially among patients with an underlying liver disease. All patients should be investigated for thrombophilic conditions, and in those with cirrhosis, anticoagulation prophylaxis should be considered |
| Disciplines | Medicina |
| Paraules clau: | Gastroenterología, Sistema cardiovascular, Trombosis venosa, Vena portal, Carcinoma hepatocelular, Cirrosis, Coagulación sanguínea, Trasplante de hígado |
| Keyword: | Medicine, Cardiovascular system, Gastroenterology, Venous thrombosis, Portal vein, Hepatocellular carcinoma, Cirrhosis, Blood coagulation, Liver transplantation |
| Text complet: | Texto completo (Ver PDF) |
