Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: a closer look at the role of siderosis
Título del documento: Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: a closer look at the role of siderosis
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000418128
ISSN: 1665-2681
Autors: 1
2
2
1
1
Institucions: 1American University of Beirut, Medical Center, Beirut. Líbano
2Universita di Milano, Ospedale Maggiore Policlinico, Milán, Lombardia. Italia
Any:
Període: Feb
Volum: 12
Número: 1
Paginació: 142-146
País: México
Idioma: Inglés
Tipo de documento: Revisión bibliográfica
Enfoque: Caso clínico
Resumen en inglés Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC)
Disciplines Medicina
Paraules clau: Gastroenterología,
Hematología,
Talasemia,
Carcinoma hepatocelular,
Depósitos de hierro,
Hígado,
Sobrecarga de hierro,
Factores de riesgo
Keyword: Gastroenterology,
Hematology,
Thalassemia,
Hepatocellular carcinoma,
Iron deposits,
Liver,
Iron overload,
Risk factors
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