| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411782 |
| ISSN: | 1665-2681 |
| Autors: | Marcello Persico1 Coppola, Nicola2 Rosato, Valerio3 Abenavoli, Ludovico4 Masarone, Mario1 Luna, Antonio De5 |
| Institucions: | 1Universita di Salerno, Unita di Hepatologia, Baronissi. Italia 2Seconda Universita di Napoli, Dipartimento di Salute Mentale, Nápoles, Campania. Italia 3Seconda Universita di Napoli, Dipartimento di Medicina Interna e Epatologia, Nápoles, Campania. Italia 4Universita Magna Graecia, Scienze della Vita, Catanzaro, Calabria. Italia 5Azienda Sanitaria Locale, Distretto 65, Battipaglia, Salerno. Italia |
| Any: | 2015 |
| Període: | May-Jun |
| Volum: | 14 |
| Número: | 3 |
| Paginació: | 325-332 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Hepatitis C infection is very common among injection drug users(IDUs). In clinical practice there is reluctance to treat IDUs, because considered difficult-to-treat. Aim of this study was to evaluate the response to antiviral treatment in IDUs compared to non-IDUs. Main results. In this observational retrospective study, 204 non cirrhotic patients(112 IDUs, 92 non-IDUs) with chronic hepatitis C, treated with PEG-IFN and ribavirin in a tertiary centre for IDUs of Southern Italy from 2008 to 2011 were analyzed. Age, sex, genotype, steatosis, response to previous therapy, rapid(RVR), early(EVR), end-of-treatment(ETR), sustained(SVR) virological response were evaluated. IDUs were mainly young and males, with prevalence of genotype 3. A higher SVR rate in IDUs group compared to non-IDUs only in PerProtocol(PP) analysis (90% vs. 78,9% ;p = 0.04). On the contrary, in IntentionToTreat(ITT) analysis, no significant difference was relieved. A higher SVR rate at ITT analyses in naïve non-IDUs patients was found (76,13% vs. 90%, p = 0.021), but at PP analysis wasn’t confirmed. Treatment was well tolerated; a higher dropout rate was reported in IDUs (24 patients) compared to non-IDUs (2 patients). In order to exclude the effect of viral genotypes on SVR a genotype matched statistical analysis was done and no difference was found. Conclusions. IDUs naïve patients, due to young age and high prevalence of genotype 3, appear good candidates to dual antiviral therapy with high SVR rates. Dropout is the main non-response cause among these subjects, but through an optimal monitoring program with a multidisciplinary setting, their “difficult to treat” characteristics can be overcome |
| Disciplines | Medicina |
| Paraules clau: | Gastroenterología, Hepatitis C, Hepatitis crónica, Drogas inyectables, Drogadictos, Terapia antiviral |
| Keyword: | Medicine, Gastroenterology, Hepatitis C, Chronic hepatitis, Injectable drugs, Drugaddicts, Antiviral therapy |
| Text complet: | Texto completo (Ver PDF) |
