Glycogenic hepatopathy associated with type 1 diabetes mellitus as a cause of recurrent liver damage



Título del documento: Glycogenic hepatopathy associated with type 1 diabetes mellitus as a cause of recurrent liver damage
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000419232
ISSN: 1665-2681
Autors: 1
1
1
1
1
Institucions: 1Universita di Firenze, Centro di Ricerca, Florencia, Toscana. Italia
Any:
Període: Jul-Ago
Volum: 11
Número: 4
Paginació: 554-558
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico
Resumen en inglés Aminotransferase elevation is a frequent cause of consultation for the Hepatologist, in both the outpatient and inpatient settings, but identifying the origin of these biochemical alterations may be challenging. Here we report a case where acute elevation of aminotransferases, associated with abdominal symptoms, was the cause of two hospitalizations in a short period of time. As the patient suffered from type 1 diabetes, celiac disease, and autoimmune thyroiditis, several potential causes of damage could be hypothesized, including celiac hepatitis, fatty liver, and autoimmune hepatitis. A liver biopsy performed in the occasion of the second hospitalization allowed to rule out autoimmune hepatitis and celiac hepatitis, showing mild signs of fatty infiltration. Staining with periodic acid-Schiff with or without diastase showed a marked accumulation of glycogen, indicating the presence of a glycogenic hepatopathy associated with poorly controlled type 1 diabetes. This condition may be a cause of liver damage in patients with type 1 and occasionally type 2 diabetes, but its occurrence is often overlooked. This case report illustrates the fact that glycogenic hepatopathy may relapse, and prompts the clinician to take into account this condition in the differential diagnosis of causes of liver injury
Disciplines Medicina
Paraules clau: Gastroenterología,
Metabolismo y nutrición,
Bioquímica,
Hígado graso no alcohólico,
Enfermedad celíaca,
Hepatitis,
Hepatitis autoinmune
Keyword: Gastroenterology,
Metabolism and nutrition,
Biochemistry,
Non alcoholic fatty liver,
Celiac disease,
Hepatitis,
Autoimmune hepatitis
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