| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000412946 |
| ISSN: | 1665-2681 |
| Autors: | Paranagua-Vezozzo, Denise C1 Ono, Suzane K1 Alvarado-Mora, Mónica V1 Farias, Alberto Q1 Cunha-Silva, Marlone2 Franca, Joao I.D2 Alves, Venancio A.F1 Sherman, Morris3 Carrilho, Flair Jose1 |
| Institucions: | 1Universidade de Sao Paulo, Hospital de Clinicas, Sao Paulo. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil 3University of Toronto, Department of Gastroenterology, Toronto, Ontario. Canadá |
| Any: | 2014 |
| Període: | Jul-Ago |
| Volum: | 13 |
| Número: | 4 |
| Paginació: | 386-393 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Estadística o encuesta |
| Enfoque: | Analítico |
| Resumen en inglés | The lack of information about hepatocellular carcinoma (HCC) in Brazil weakens health policy in preventing deaths from the illness. The aim of this study was to establish the cumulative incidence and the risk factors for hepatocellular carcinoma development in patients under a surveillance program. Material and methods. 884 patients with compensated cirrhosis were prospectively followed up for at least five years, from August 1998 until August 2008, with at least one annual ultrasonography liver examination and serum alpha fetoprotein (AFP) measurement. Results. Among 884 patients, 72 (8.1%) developed a tumor with a median follow up of 21.4 months. In the hepatocellular carcinoma group, hepatitis C virus infection was the major etiological factor (65.3%), 56.9% (41/72) were male and the mean average age was 57 ± 10 years. The annual incidence of hepatocellular carcinoma was 2.9%. 79.2% (57/72) of HCCs were detected within Milan Criteria, and the mean survival time was 52.3 months, significantly higher than for those outside Milan, with a mean time of 40.6 months (p = 0.0003). Conclusion. The annual incidence of HCC among this large series of Brazilian cirrhotic patients was around 2.9% with a detection rate of 8.1%, or a cumulative incidence rate over five years of 14.3%. The three variables related to HCC risk were low serum albumin [HR: 0.518 (0.46-0.78)], high AFP > 20 ng/mL [HR: 3.16 (1.86-5.38)], and ethnicity (Brazilian-East Asian descendants vs. other mixed Brazilian ethnicities) [HR: 2.86 (1.48-5.53)] |
| Disciplines | Medicina |
| Paraules clau: | Gastroenterología, Oncología, Salud pública, Carcinoma hepatocelular, Ultrasonografía, Criterios de Milán, Factores de riesgo, Vigilancia, Epidemiología, Hepatitis C |
| Keyword: | Medicine, Gastroenterology, Oncology, Public health, Hepatocellular carcinoma, Ultrasonography, Milan criteria, Risk factors, Surveillance, Epidemiology, Hepatitis C |
| Text complet: | Texto completo (Ver PDF) |
