| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000407475 |
| ISSN: | 1665-2681 |
| Autors: | Gallach, Marta1 Vergara, Mercedes1 Miquel, Mireia1 Casas, Meritxell1 Sánchez Delgado, Jordi1 Dalmau, Blai1 Gil, Montserrat1 Rudi, Núria1 Parra, Isabel1 López, Maria1 Dosal, Angelina1 Moreno, Laura1 Valero, Oliver2 Calvet, Xavier1 |
| Institucions: | 1Universidad Autónoma de Barcelona, Hospital de Sabadell, Sabadell. España 2Universidad Autónoma de Barcelona, Departamento de Estadística Aplicada, Barcelona. España |
| Any: | 2016 |
| Període: | Jul-Ago |
| Volum: | 15 |
| Número: | 4 |
| Paginació: | 524-531 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Despite the introduction of direct antiviral agents, pegylated interferon remains the mainstay of treatment for chronic hepatitis C. However, pegylated interferon is associated with a high rate of severe adverse events and decreased quality of life. Specific interventions can improve adherence and effectiveness. We aimed to determine whether implementing a multidisciplinary approach improved outcomes in the treatment of chronic hepatitis C. Material and methods. Material and methods. Material and methods. We analyzed consecutive patients treated with pegylated interferon plus ribavirin between August 2001 and December 2011. We compared patients treated before and after the implementation of a multidisciplinary approach in 2007. We compared the baseline demographic and clinical characteristics and laboratory findings between groups, and used bivariate logistic regression models to detect factors involved in attaining a sustained virological response, calculating the odds ratios with their respective 95% confidence intervals. To evaluate the effect of the multidisciplinary team, we fitted a multivariate logistic regression model to compare the sustained virological response after adjusting for unbalanced variables and predictive factors. Results. Results. We included 514 patients [228 (44.4%) in the pre-intervention cohort]. Results. Age, viral genotype, previous treatment, aspartate transaminase, ferritin, and triglyceride were prognostic factors of sustained virological response. After adjusting for prognostic factors, sustained virological response was higher in the multidisciplinary cohort (58 vs. 48%, p = 0.038). Despite higher psychiatric comorbidity and age in the multidisciplinary cohort, we observed a trend toward a lower rate of treatment abandonment in this group (2.2 vs. 4.9%, p = 0.107). Conclusion. Conclusion. Conclusion. Multidisciplinary management of chronic hepatitis C improves outcomes |
| Disciplines | Medicina |
| Paraules clau: | Farmacología, Gastroenterología, Hepatitis C, Hepatitis crónica, Terapia antiviral, Adherencia al tratamiento, Interferón pegilado, Ribavirina, Efectos adversos |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Hepatitis C, Chronic hepatitis, Antiviral therapy, Treatment adherence, Pegylated interferon, Ribavirin, Adverse effects |
| Text complet: | Texto completo (Ver PDF) |
