Cytokeratin19 positive hepatocellular carcinoma is associated with increased peritumoral ductular reaction
Título del documento: Cytokeratin19 positive hepatocellular carcinoma is associated with increased peritumoral ductular reaction
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000411635
ISSN: 1665-2681
Autors: 1
2
1
1
1
1
3
1
Institucions: 1Shanghai Jiaotong University, School of Medicine, Shanghai. China
2Fudan University, Zhongshan Hospital, Shanghai. China
3Second Military Medical University, Eastern Hepatobiliary Surgery Hospital, Shanghai. China
Any:
Període: May-Jun
Volum: 15
Número: 3
Paginació: 386-393
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, analítico
Resumen en inglés Background and aims. Cytokeratin19 positive (CK19+) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19+ and CK19 negative (CK19- ) HCC patients remains unclear. Material and methods. Material and methods. One Material and methods. hundred and twenty HBV-related HCC patients were enrolled in this study. Clinicopathological variables were collected, and immunohistochemistry staining for CK19, proliferating cell nuclear antigen (PCNA), interleukin-6 (IL-6) and β-catenin were performed in tumor and peritumor liver tissues. Results. Results. CK19 Results. + HCC patients had higher grade of peritumoral DR and proportion of proliferative DR than the CK19- group. The mean number or the proportion of cytoplasmic β-catenin+ DR was higher in the CK19+ group than in the CK19- group. Furthermore, there were more patients with nuclear β-catenin+ peritumoral DR in the CK19+ group as compared to the CK19- group. Conclusion. Conclusion. Conclusion. Peritumoral DR was more abundant and proliferative in CK19+ HCC patients, with higher level of nuclear translocation of β-catenin. However, it is unclear whether peritumoral DR is the cause or result of poor prognosis in these patients
Disciplines Medicina
Paraules clau: Gastroenterología,
Oncología,
Carcinoma hepatocelular,
Células progenitoras,
Beta catenina,
Citoqueratina
Keyword: Medicine,
Gastroenterology,
Oncology,
Hepatocellular carcinoma,
Progenitor cells,
Beta catenin,
Cytokeratin
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