| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411787 |
| ISSN: | 1665-2681 |
| Autors: | Younis, Irfan1 Sarwar, Shahid2 Butt, Zeeshan3 Tanveer, Sheharyar4 Qaadir, Adnan5 Jadoon, Nauman Arif6 |
| Institucions: | 1Nawaz Sharif Medical College, Gujarat. Pakistán 2King Edward Medical University, Lahore, Punjab. Pakistán 3Prince George’s Hospital Center, Cheverly, Maryland. Estados Unidos de América 4Services Hospital, Lahore, Punjab. Pakistán 5Military Hospital, Rawalpindi. Pakistán 6Center for Biomedical Research, Lahore, Punjab. Pakistán |
| Any: | 2015 |
| Període: | May-Jun |
| Volum: | 14 |
| Número: | 3 |
| Paginació: | 354-360 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Hepatopulmonary syndrome (HPS) is a complication of advanced liver disease. The impact of HPS on survival is not clearly understood. Material and methods. A prospective study was carried out at Department of Medicine, King Edward Medical University Lahore from June 2011 to May 2012. Patients with cirrhosis of liver were evaluated for presence of HPS with arterial blood gas analysis and saline bubble echocardiography. All patients were followed for 6 months for complications and mortality. Cox regression analysis was done to evaluate role of HPS on patient survival. Results. 110 patients were included in the study. Twenty-nine patients (26%) had HPS. MELD score was significantly higher (p < 0.01) in patients with HPS (18.93 ± 3.51) as compared to that in patients without HPS (13.52 ± 3.3). Twenty two (75.9%) patients of Child class C, 5 (17.2%) patients of Child class B and 2 (6.9%) patients of Child class A had HPS (P 0.03). The clinical variables associated with presence of HPS were spider nevi, digital clubbing, dyspnea, and platypnea. HPS significantly increased mortality during six month follow up period (HR: 2.47, 95% CI: 1.10- 5.55). Child-Pugh and MELD scores were also associated with increased mortality. HPS was no longer associated with mortality when adjustment was done for age, gender, Child-Pugh, and MELD scores (HR: 0.44, 95% CI: 0.14-1.41). Both the Child-Pugh and MELD scores remained significantly associated with mortality in the multivariate survival analysis. Conclusions. HPS indicates advanced liver disease. HPS does not affect mortality when adjusted for severity of cirrhosis |
| Disciplines | Medicina |
| Paraules clau: | Gastroenterología, Neumología, Síndrome hepatopulmonar, Hipoxemia, Platipnea, Mortalidad |
| Keyword: | Medicine, Gastroenterology, Pneumology, Hepatopulmonary syndrome, Hypoxemia, Platypnea, Mortality |
| Text complet: | Texto completo (Ver PDF) |
