| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436306 |
| ISSN: | 0001-3765 |
| Autors: | Giustina, Amanda D1 Danielski, Lucinéia G1 Novochadlo, Michele M1 Goldim, Mariana P.S1 Joaquim, Larissa1 Metzker, Kiuanne L.L1 Carli, Raquel Jaconi de1 Denicol, Tais1 Cidreira, Thaina1 Vieira, Thaynan1 Petrolinho, Fabricia1 |
| Institucions: | 1Universidade do Sul de Santa Catarina, Unidade de Ciencias da Saude, Tubarao, Santa Catarina. Brasil |
| Any: | 2019 |
| Volum: | 91 |
| Número: | 4 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver were harvest for neutrophil infiltration, oxidative markers to lipids and protein and antioxidant activity of endogenous enzyme. Vitamin B6 diminished neutrophil infiltration in both organs, oxidative markers in the liver and restored catalase activity levels in the lung of septic animals. Vitamin B6 exerts anti-inflammatory and antioxidant effects in peripheral organs after polymicrobial sepsis |
| Disciplines | Medicina |
| Paraules clau: | Microbiología, Farmacología, Infección experimental, Sepsis, Pulmones, Vitamina B6, Estrés oxidativo, Antioxidantes |
| Keyword: | Microbiology, Pharmacology, Experimental infection, Sepsis, Lungs, Vitamin B6, Oxidative stress, Antioxidants |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
