| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000435810 |
| ISSN: | 0001-3765 |
| Autores: | Afonso, Arlindo C1 Pacheco, Felipe D1 Canever, Lara1 Wessler, Patricia G1 Mastella, Gustavo A1 Godoi, Amanda K1 Hubbe, Isabela1 Bischoff, Laura M1 Bialecki, Alex Victor S1 Zugno, Alexandra I1 |
| Instituciones: | 1Universidade do Extremo Sul Catarinense, Programa de Pos-graduacao em Ciencias da Saude, Criciuma, Santa Catarina. Brasil |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 4 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | An emerging area in schizophrenia research focuses on the impact of immunomodulatory drugs such as melatonin, which have played important roles in many biological systems and functions, and appears to be promising. The objective was to evaluate the effect of melatonin on behavioral parameters in an animal model of schizophrenia. For this, Wistar rats were divided and used in two different protocols. In the prevention protocol, the animals received 1 or 10mg/kg of melatonin or water for 14 days, and between the 8th and 14th day they received ketamine or saline. In the reversal protocol, the opposite occurred. On the 14th day, the animals underwent behavioral tests: locomotor activity and prepulse inhibition task. In both protocols, the results revealed that ketamine had effects on locomotor activity and prepulse inhibition, confirming the validity of ketamine construction as a good animal model of schizophrenia. However, at least at the doses used, melatonin was not able to reverse/prevent ketamine damage. More studies are necessary to evaluate the role of melatonin as an adjuvant treatment in psychiatric disorders |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Psiquiatría, Medicina experimental, Esquizofrenia, Melatonina, Modelos animales, Ketamina, Roedores |
| Keyword: | Pharmacology, Psychiatry, Experimental medicine, Schizophrenia, Melatonin, Animal models, Rodents, Ketamine |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
