| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000408986 |
| ISSN: | 0001-3765 |
| Autors: | Soares, Debora B.S1 Duarte, Lucienir P1 Cavalcanti, Andre D2 Silva, Fernando C3 Braga, Ariadne D4 Lopes, Miriam T.P4 |
| Institucions: | 1Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil 2Departamento de Policia Federal de Minas Gerais, Setor Tecnico-Cientifico, Belo Horizonte, Minas Gerais. Brasil 3Universidade do Estado de Minas Gerais, Unidade de Divinopolis, Divinopolis, Minas Gerais. Brasil 4Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 5Universidade Federal de Ouro Preto, Escola de Farmacia, Ouro Preto, Minas Gerais. Brasil |
| Any: | 2017 |
| Període: | Jun |
| Volum: | 89 |
| Número: | 2 |
| Paginació: | 927-938 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1 |
| Disciplines | Biología, Química |
| Paraules clau: | Angiospermas, Fitoquímica, Metabolitos secundarios, Actividad antitumoral, N,N-dimetiltriptamina, Psychotria viridis, Rubiaceae |
| Keyword: | Biology, Chemistry, Angiosperms, Phytochemistry, Secondary metabolites, Antitumoral activity, N,N-dimethyltryptamine, Psychotria viridis, Rubiaceae |
| Text complet: | Texto completo (Ver HTML) |
